Assay kits are available for DNA supercoiling, DNA relaxation, DNA cleavage and ATP hydrolysis activities of various DNA topoisomerases.

DNA Relaxation and DNA Supercoiling Assays

H19 Dye for DNA Relaxation and Supercoiling Assays: Fluorescence-based high throughput assays for DNA supercoiling and DNA relaxation activities of DNA topoisomerases in a 96-well or 384-well plate format.

Topoisomerase DNA relaxation assays

Gyrase DNA supercoiling assays

DNA Decatenation Assays

DDC Spin-columns for DNA decatenation assays: Spin-columns that separates decatenated DNA from concatenated DNA; For measurement of DNA decatenation activity.

96-well Topoisomerase DNA Decatenation Assay Kits: For measurement of DNA decatenation activity of topoisomerases in a 96-well plate format.

Topoisomerase ATPase Assays

Topoisomerase ATPase Assay Kits: For measurement of ATPase activity of topoisomerases in a 384-well plate format.

Topoisomerase DNA Cleavage Assays

96-well Topoisomerase DNA Cleavage Assay Kits: For measurement of DNA cleavage activity of topoisomerase drugs or inhibitors in a 96-well plate format.